Publication
FEATURED PUBLICATION (* lead author)
HOST-PATHOGEN INTERACTION
Kim J*, Lee KT*, Lee JS, Shin J, Cui B, Yang K, Choi N, Lee SH, Cheon J, Bahn YS*, Cho SW*.
Nature Biomedical Engineering 2021 August, 5(8):830-846
2020 IF=25.671, JIF 0.56% in Engineering, Biomedical
Selected as a cover article
등록특허: 뇌혈관 모사용 미세유체 디바이스 및 이를 포함하는 고효율 혈액뇌관문 모사 시스템(1023958010000, 2022.05.03)
Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans.
Lee KT*, Hong J*, Lee DG*, Lee M, Cha S, Lim YG, Jung KW, Hwangbo A, Lee Y, Yu SJ, Chen YL, Lee JS, Cheong E*, Bahn YS*.
Nature Communications 2020 March, 11:1521
2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences
Choi JT*, Choi Y, Lee Y, Lee SH, Kang S, Lee KT*, Bahn YS*.
PLoS Pathogens 2023 October
2022 IF=6.7, JIF 9.5% in Parasitology
FUNGAL SIGNALING NETWORKS
Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans.
Jin JH*, Lee KT*, Hong J, Lee D, Jang EH, Kim JY, Lee Y, Lee SH, So YS, Jung KW, Lee DG, Jeong E, Lee M, Jang, YB, Choi Y, Lee MH, Kim JS, Yu SR, Choi, JT, La JW, Choi H, Kim SW, Seo KJ, Lee Y, Thak EJ, Choi J, Averette AF, Lee YH, Heitman J, Kang HA, Cheong E, Bahn YS*.
Nature Communications 2020 August, 11:4212
2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences
관련 등록특허 7건
Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans.
Lee KT*, So YS*, Yang DH*, Jung KW, Choi J, Lee DG, Kwon H, Jang J, Wang LL, Cha S, Meyers GL, Jeong E, Jin JH, Lee Y, Hong J, Bang S, Ji JH, Park G, Byun HJ, Park SW, Park YM, Adedoyin G, Kim T, Averette AF, Choi JS, Heitman J, Cheong E, Lee YH, Bahn YS*.
Nature Communications 2016 September, 7:12766
2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences
Systematic functional profiling of transcription factor networks in Cryptococcus neoformans.
Jung KW*, Yang DH*, Maeng S, Lee KT, So YS, Hong J, Choi J, Byun HJ, Kim H, Bang S, Song MH, Lee JW, Kim MS, Kim SY, Ji JH, Park G, Kwon H, Cha S, Meyers GL, Wang LL, Jang J, Janbon G, Adedoyin G, Kim T, Averette AK, Heitman J, Cheong E, Lee YH, Lee YW, Bahn YS*.
Nature Communications 2015 April, 6:6757
2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences
등록특허 7건
크립토코커스 네오포르만스의 체온에 대한 내열성을 조절하는 포스파타아제 및 이를 이용한
항진균제 스크리닝 방법(1025187420000, 2021.11.17)
크립토코커스 네오포르만스의 혈액뇌장벽 통과를 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법(1025187640000, 2021.11.17)
크립토코커스 네오포르만스의 멜라닌 생산을 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법(1025187500000, 2023.04.03)
크립토코커스 네오포르만스의 다당류 캡슐 생산을 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법(1025187560000, 2023.04.03)
크립토코커스 네오포르만스의 세포막 안정성을 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법( 1025187850000, 2023.04.03)
크립토코커스 네오포르만스의 DNA 손상 반응을 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법( 1025187690000, 2023.04.03)
크립토코커스 네오포르만스의 O-만노실화를 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법(1025187860000, 2023.04.03)
ANTIFUNGAL DRUG DEVELOPMENT
Optimization and evaluation of novel antifungal agents for the treatment of fungal infection.
Choi JW*, Lee KT*, Kim S, Lee, YR, Kim H, Seo KJ, Lee MH, Yeon SK, Jang BK, Park SJ, Kim HJ, Park JH, Kim D, Lee DG, Cheong E, Lee JS*, Bahn YS*, Park KD*.
Journal of Medicinal Chemistry 2021 October, 64(21):15912–15935
2020 IF=7.446, JIF 4.03% in Medicinal Chemistry
Selected as a cover article
등록특허: 신규한 아미노알칸산에 바이페닐기를 도입한 유도체 화합물 및 이를 포함하는 항진균성 약학적 조성물(1022868970000, 2021.08.02)
Biosynthesis of nonimmunosuppressive FK506 analogues with antifungal activity
Beom JY*, Jung JA*, Lee KT*, Hwangbo A*, Song MC, Lee Y, Lee SJ, Oh JH, HA SJ, Nam SJ, Cheong E*, Bahn YS*, Yoon YJ*. Journal of Natural Products 2019 August, 82(8):2078-2086
2020 IF=4.050, JIF 6.8% in Plant Sciences
ACS Editors’ Choice
등록특허 2건: 신규 화합물 및 이를 포함하는 진균감염 치료용 약학적 조성물(1021091680000, 2020.05.04); 신규 화합물 및 이를 포함하는 신경계 질환 치료용 약학적 조성물(1021347820000, 2020.07.10)
Full list of publications are listed and linked below.
2024
Soohyun Um, Hyeongju Jeong, Ji-Eun Park, Jeongwon Seo, Kyung-Tae Lee*, Kyuho Moon *. Isolation and Characterization of Bioactive Compounds from Saccharomonospora sp. CMS18 and Their Antifungal Properties. Marine Drugs 2024, 22(12), 539. https://doi.org/10.3390/md22120539 (IF=4.9, JIF 12.6%)
Kwang-Woo Jung*, Seung-Heon Lee*, Kyung-Tae Lee*, Yong-Sun Bahn*. Sensing and Responding to Host-Derived Stress Signals: Lessons from fungal meningitis pathogen. Current Opinion in Microbiology. 2024 Aug:80:102514. http://doi.org/10.1016/j.mib.2024.102514 (IF=5.9; JIF 13.4%)
Sunhak Kwon, Yeseul Choi, Eui-Seong Kim, Kyung-Tae Lee, Yong-Sun Bahn, and Kwang-Woo Jung. Pleitropic roles of LAMMER kinase, Lkh1 in stress response and virulence of Cryptococcus neoformans. Frontiers in Cellular & Infection Microbiology. 2024 May 7:14:1369301. http://doi.org/10.3389/fcimb.2024.1369301
2023
Ye-Eun Son, Jiwoo Han, Kyung-Tae Lee and Hee-Soo Park. Pleiotropic functions of SscA on the asexual spore of the human pathogenic fungus Aspergillus fumigatus. Mycology. 2023 Dec 25;15(2):238-254. http://doi.org/10.1080/21501203.2023.2294061
Jin-Tae Choi, Yeseul Choi, Yujin Lee, Seung-Heon Lee, Seun Kang, Kyung-Tae Lee*, Yong-Sun Bahn*. The hybrid RAVE Complex plays V-ATPase-dependent and -independent pathobiological roles in Cryptococcus neoformans. PLoS Pathogens. 2023 Oct 9;19(10):e1011721. http://doi.org/10.1371/journal.ppat.1011721 (IF=6.7; JIF 9.5%)
Ji-Seok Kim, Kyung-Tae Lee, Yong-Sun Bahn. Secreted aspartyl protease 3 (Sapa3) regulated by the Ras/cAMP/PKA pathway promotes the virulence of Candida auris. Frontiers in Cellular and Infection Microbiology. 2023 Sep 15:13:1257897. http://doi.org/10.3389/fcimb.2023.1257897
Ji-Seok Kim, Kyung-Tae Lee*, Yong-Sun Bahn*. Deciphering the regulatory mechanisms of the cAMP/protein kinase A pathway and their roles in the pathogenicity of Candida auris. Microbiology Spectrum. 2023 Sep 6;11(5):e0215223. http://doi.org/10.1128/spectrum.02152-23
등록특허: cAMP/PKA 신호전달경로 인자 저해제를 포함하는 항진균 보조용 조성물(1027216290000, 2024.10.21)
Yeongwoon Jin*, Kyung-Tae Lee*, Taeyeon Kim, Jaekyeong Kim, Jin Woo Lee, and Sang Hee Shim*. New secondary metabolites produced by Paraphoma radicina FB55 as potential antifungal agents. Journal of Antibiotics. 2023 Aug;76(8):474-480. http://doi.org/s41429-023-00626-x
2022
Ioanna Leontiou, Thomas Davies, Ivan Clark, Koly Aktar, Ardra Pamburayath Suresh, Maria Alba Abad, Christos Spanos, Kyung-Tae Lee, Yong-Sun Bahn, A. Arockia Jeyaprakash, and Kevin G. Hardwick*. Bub1 kinase acts as a signalling hub for the entire Cryptococcus neoformans spindle assembly checkpoint pathway. bioRxiv 2022 September. https://doi.org/10.1101/2022.09.21.508923
Lee KT*, Lee DG, Choi JW, Park JH, Park KD, Lee JS*, YS Bahn*. The novel antifungal agent AB-22 displays in vitro activity against hyphal growth and biofilm formation in Candida albicans and potency for treating systemic candidiasis. Journal of Microbiology 2022 April, 60(4):438-443. http://doi.org/10.1007/s12275-022-2016-0
2021
Choi JW*, Lee KT*, Kim S, Lee, YR, Kim H, Seo KJ, Lee MH, Yeon SK, Jang BK, Park SJ, Kim HJ, Park JH, Kim D, Lee DG, Cheong E, Lee JS*, Bahn YS*, Park KD*. Optimization and evaluation of novel antifungal agents for the treatment of fungal infection. Journal of Medicinal Chemistry 2021 October, 64(21):15912–15935. http://doi.org/10.1021/acs.jmedchem.1c01299 (2020 IF=7.446, JIF 4.03% in Medicinal Chemistry, Selected as a cover article)
Kim JS*, Lee KT, Lee MH, Cheong E, Bahn YS*. Adenylyl cyclase and protein kinase A play redundant and distinct roles in growth, differentiation, antifungal drug resistance, and pathogenicity of Candida auris. mBio 2021 October, 12(5):e02729-21. http://doi.org/10.1128/mBio.02729-21
Kim J*, Lee KT*, Lee JS, Shin J, Cui B, Yang K, Choi N, Lee SH, Cheon J, Bahn YS*, Cho SW*. Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood-brain barrier. Nature Biomedical Engineering 2021 August, 5(8):830-846. http://doi.org/10.1038/s41551-021-00743-8 (2020 IF=25.671, JIF 0.56%, Selected as a cover article)
2020
Jung KW*, Lee KT, Bahn YS*. A signature-tagged mutagenesis (STM)-based murine-infectivity assay for Cryptococcus neoformans. Journal of Microbiology 2020 October, 58(10):823-831. http://doi.org/10.1007/s12275-020-0341-8
Jin JH*, Lee KT*, Hong J, Lee D, Jang EH, Kim JY, Lee Y, Lee SH, So YS, Jung KW, Lee DG, Jeong E, Lee M, Jang, YB, Choi Y, Lee MH, Kim JS, Yu SR, Choi, JT, La JW, Choi H, Kim SW, Seo KJ, Lee Y, Thak EJ, Choi J, Averette AF, Lee YH, Heitman J, Kang HA, Cheong E, Bahn YS*. Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans. Nature Communications 2020 August, 11:4212. http://doi.org/10.1038/s41467-020-18028-0 (2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences)
Lee KT*, Hong J*, Lee DG*, Lee M, Cha S, Lim YG, Jung KW, Hwangbo A, Lee Y, Yu SJ, Chen YL, Lee JS, Cheong E*, Bahn YS*. Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans. Nature Communications 2020 March, 11:1521. http://doi.org/10.1038/s41467-020-15329-2 (2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences, F1000 recommended)
2019
So YS*, Maeng S*, Yang DH, Kim H, Lee KT, Yu SR, Tenor J, Giri VK, Toffaletti DL, Arras S, Fraser JA, Perfect JR, Bahn YS*. Regulatory mechanism of the atypical AP-1-like transcription factor Yap1 in Cryptococcus neoformans. mSphere 2019 November, 4(6):e00785-19. http://doi.org/10.1128/mSphere.00785-19
Lee D*, Jang EH, Lee M, Kim SW, Lee Y, Lee KT, Bahn YS*. Unraveling melanin biosynthesis and signaling networks in Cryptococcus neoformans. mBio 2019 October, 10(5):e02267-19. http://doi.org/10.1128/mBio.02267-19 (Editor's Pick, F1000 recommended)
Beom JY*, Jung JA*, Lee KT*, Hwangbo A*, Song MC, Lee Y, Lee SJ, Oh JH, HA SJ, Nam SJ, Cheong E*, Bahn YS*, Yoon YJ*. Biosynthesis of nonimmunosuppressive FK506 analogues with antifungal activity. Journal of Natural Products 2019 August, 82(8):2078-2086. http://doi.org/10.1021/acs.jnatprod.9b00144 (2020 IF=4.050, JIF 6.8% in Plant Sciences, ACS Editors’ Choice)
2018
Lee Y*, Lee KT*, Lee SJ*, Beom JY*, Hwangbo A, Jung JA, Song MC, Yoo YJ, Kang SH, Averette AF, Heitman J, Yoon YJ*, Cheong E*, Bahn YS*. In vitro and in vivo assessment of FK506 analogs as novel antifungal drug candidates. Antimicrobial Agents and Chemotherapy 2018 November, 62(11):e01627-18. http://doi.org/10.1128/AAC.01627-18
Jung KW*, Lee KT, So YS, Bahn YS*. Genetic Manipulation of Cryptococcus neoformans. Current Protocols in Microbiology 2018 August, 50(1):e59. http://doi.org/10.1002/cpmc.59
Jung KW*, Lee KT, Averette AF, Hoy MJ, Everitt J, Heitman J, Bahn YS*. Evolutionarily conserved and divergent roles of unfolded protein response (UPR) in the pathogenic Cryptococcus species complex. Scientific Reports 2018 May, 8(1):8132. http://doi.org/10.1038/s41598-018-26405-5
Wang LL*, Lee KT*, Jung KW, Lee DG, Bahn YS*. The novel microtubule-associated CAP-glycine protein Cgp1 governs growth, differentiation, and virulence of Cryptococcus neoformans. Virulence 2018 February, 9(1):566-584. http://doi.org/10.1080/21505594.2017.1423189
Previous Studies
Lee KT*, So YS*, Yang DH*, Jung KW, Choi J, Lee DG, Kwon H, Jang J, Wang LL, Cha S, Meyers GL, Jeong E, Jin JH, Lee Y, Hong J, Bang S, Ji JH, Park G, Byun HJ, Park SW, Park YM, Adedoyin G, Kim T, Averette AF, Choi JS, Heitman J, Cheong E, Lee YH, Bahn YS*. Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans. Nature Communications 2016 September, 7:12766. http://doi.org/10.1038/ncomms12766 (2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences, F1000 recommended)
Gonzalez-Hilarion S, Paulet D, Lee KT, Hon CC, Lechat P, Mogensen E, Moyrand F, Proux C, Barboux R, Bussotti G, Hwang J, Coppée JY, Bahn YS, Janbon G*. Intron retention-dependent gene regulation in Cryptococcus neoformans. Scientific Reports 2016 August, 6:32252. http://doi.org/10.1038/srep32252
Jung KW*, Yang DH*, Maeng S, Lee KT, So YS, Hong J, Choi J, Byun HJ, Kim H, Bang S, Song MH, Lee JW, Kim MS, Kim SY, Ji JH, Park G, Kwon H, Cha S, Meyers GL, Wang LL, Jang J, Janbon G, Adedoyin G, Kim T, Averette AK, Heitman J, Cheong E, Lee YH, Lee YW, Bahn YS*. Systematic functional profiling of transcription factor networks in Cryptococcus neoformans. Nature Communications 2015 April, 6:6757. http://doi.org/10.1038/ncomms7757 (2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences, F1000 recommended)
Lee KT*, Lee JW, Lee D, Jung WH, Bahn YS*. A ferroxidase, Cfo1, regulates diverse environmental stress responses of Cryptococcus neoformans through the HOG pathway. Mycobiology 2014 June, 42(2):152-157. http://doi.org/10.5941/MYCO.2014.42.2.152
Lee KT*, Byun HJ*, Jung KW*, Hong J, Cheong E, Bahn YS*. Distinct and redundant roles of protein tyrosine phosphatases Ptp1 and Ptp2 in governing the differentiation and pathogenicity of Cryptococcus neoformans. Eukaryotic Cell 2014 May, 13(6):796-812. http://doi.org/10.1128/EC.00069-14
Lee KT*, Kwon H, Lee D, Bahn YS*. A nudix hydrolase protein, Ysa1, regulates oxidative stress response and antifungal drug susceptibility in Cryptococcus neoformans. Mycobiology 2014 March, 42(1):52-58. http://doi.org/10.5941/MYCO.2014.42.1.52
PhD Thesis
Lee KT*. Systematic analysis of the pathogenicity-related signal pathways in human meningitis fungal pathogen. Graduate School, Yonsei University Department of Biotechnology (2018) RISS: http://www.riss.kr/link?id=T14739545
INVITED TALK
2024.11.06 “Discovery of principles of adaptation to host environment through isolation of fungal strains”, APSMM 2024 The 8th Congress of Asia-Pacific Society for Medical Mycology, Kyoto, Japan
2024.10.31 “Discovery of Intrinsic and Extrinsic Drug Resistance Principles through Clinical Fungal Isolates”, MSK, Jeju, Korea
2024.06.27 “Discovery of fungal drug resistance in Candida auris, a multi-drug resistant fungus, and clinical specimen isolates”, The 31st Federation Meeting of Korean Basic Medical Scientists 2024, Seoul, Korea
2024.06.21 “Discovery of drug resistance principles through fungal isolation in various environments”, KSM2024, Busan, Korea
2023.06.01 “Discovery and Evaluation of Fungal-Specific Inhibitory Effects of Natural Products”, KMB2023, Gongju, Korea
2022.10.13 “Discovering New Drug-resistance Mechanisms through the Analysis of Drug-resistant fungi in the Environment and Animals” Korea Society of Mycology: 50 years on, Cheonan, Korea
2022.04.01 “Discovering the host infection mechanism of fungal pathogens”, The 2022 KSPP Spring Conference, Byeonsan, Korea
2022.04.21 “Discovering the infection mechanism of fungal pathogen causing brain infection”
2021.10.29 “Identification of the brain infection mechanism of meningitis fungus” in preparation, The Korean Society of Mycology 2021 Korea-Japan joint symposium on mycology, Gwangju, Korea
2021.06.24 “Cryptococcal genetic regulation in host-pathogen interactions”, MSK2021, Busan, Korea
2021.06.09 “Host mimicking systems to identify the brain infection mechanism of a fungal meningitis pathogen”, BK21 Yonsei Education & Research Center for Biosystems, online-session
2021.03.18 “Genetics in fungal pathogen, technical seminar”, Food Biotechnology Lab, Yonsei University, Wonju, Korea
2021.03.18 “Identification of fungal genes regulating host pathogen interactions”, Biological Science and Technology Department Seminar, Yonsei University, Wonju, Korea
2020.08.24 “Host mimicking systems to identify the brain infection mechanism of a fungal meningitis pathogen”, MSK2020, online-session
2020.08.24 “Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans”, MSK2020, online-session
2020.01.22 “Systematic functional analysis of complex signaling networks governing fungal brain infection”, 2019 BK21 PLUS Research Symposium, Seoul, Korea
2019.08.28 “Identification of signaling networks governing the brain infection of Cryptococcus neoformans”, 2019 SRC-MSS Summer Symposium, Gwangju, Korea
2019.02.22 “Systematic functional analysis of complex signaling networks governing brain infection of Cryptococcus neoformans”, BK21 PLUS Systems Biology Center, Seoul, Korea
2018.02.08 “Systematic analysis of the pathogenicity-related signal pathways in human meningitis fungal pathogen”, The 21st Fungal Genetics and Biology Conference of the Microbiological Society of Korea, Cheonan, Korea
2017.04.26 “Systematic analysis of the pathogenicity-related signal transduction of human meningitis fungal pathogen Cryptococcus neoformans”, 2017 International Meeting of the Microbiology Society of Korea, Busan, Korea
2017.02.21 “Functional identification of the pathogenicity-related signal transduction of human meningitis fungal pathogen Cryptococcus neoformans”, BK21 PLUS Systems Biology Center, Seoul, Korea
2016.02.03 “Systematic functional profiling of transcription factor networks in Cryptococcus neoformans” BK21 PLUS Research Symposium, Seoul, Korea
2015.11.30 “Kinome webs reveal novel pathogenicity networks in a global human meningitis fungal pathogen”, BK21 PLUS Systems Biology Center, Seoul, Korea
2015.11.12 “A Novel CAP-glycine protein governs growth, differentiation, and the pathogenicity of human fungal pathogen Cryptococcus neoformans”, MICROBIAL STRESS:From Molecules to Systems, Sitges, Spain