Publication

• Inhibition of Candidalysin Production by Methoxy-Apo-Enterobactin from Streptomyces ambofaciens CJD34 as a Novel Antifungal Strategy against Candida albicans. 

Eui-Seong Kim, Hyeongju Jeong, Mustansir Abbas, Soohyun Um, Juntack Oh, Kyuho Moon*, Kyung-Tae Lee*. 

Journal of Microbiology, 2025 May accepted

• Isolation and Characterization of Bioactive Compounds from Saccharomonospora sp. CMS18 and Their Antifungal Properties.

Soohyun Um, Hyeongju Jeong, Ji-Eun Park, Jeongwon Seo, Kyung-Tae Lee*, Kyuho Moon*. 

Marine Drugs 2024, 22(12), 539. https://doi.org/10.3390/md22120539 (IF=4.9; JIF 12.6%)

• Sensing and Responding to Host-Derived Stress Signals: Lessons from fungal meningitis pathogen. 

Kwang-Woo Jung*, Seung-Heon Lee*, Kyung-Tae Lee*, Yong-Sun Bahn*. 

Current Opinion in Microbiology. 2024 Aug:80:102514. http://doi.org/10.1016/j.mib.2024.102514 (IF=5.9; JIF 13.4%)

• Pleitropic roles of LAMMER kinase, Lkh1 in stress response and virulence of Cryptococcus neoformans. 

Sunhak Kwon, Yeseul Choi, Eui-Seong Kim, Kyung-Tae Lee, Yong-Sun Bahn, and Kwang-Woo Jung. 

Frontiers in Cellular & Infection Microbiology. 2024 May 7:14:1369301. http://doi.org/10.3389/fcimb.2024.1369301

• Pleiotropic functions of SscA on the asexual spore of the human pathogenic fungus Aspergillus fumigatus. 

Ye-Eun Son, Jiwoo Han, Kyung-Tae Lee and Hee-Soo Park. 

Mycology. 2023 Dec 25;15(2):238-254. http://doi.org/10.1080/21501203.2023.2294061

• The hybrid RAVE Complex plays V-ATPase-dependent and -independent pathobiological roles in Cryptococcus neoformans. 

Jin-Tae Choi, Yeseul Choi, Yujin Lee, Seung-Heon Lee, Seun Kang, Kyung-Tae Lee*, Yong-Sun Bahn*. 

PLoS Pathogens. 2023 Oct 9;19(10):e1011721. http://doi.org/10.1371/journal.ppat.1011721 (IF=6.7; JIF 9.5%)

• Secreted aspartyl protease 3 (Sapa3) regulated by the Ras/cAMP/PKA pathway promotes the virulence of Candida auris. 

Ji-Seok Kim, Kyung-Tae Lee, Yong-Sun Bahn. 

Frontiers in Cellular and Infection Microbiology. 2023 Sep 15:13:1257897. http://doi.org/10.3389/fcimb.2023.1257897

• Deciphering the regulatory mechanisms of the cAMP/protein kinase A pathway and their roles in the pathogenicity of Candida auris. 

Ji-Seok Kim, Kyung-Tae Lee*, Yong-Sun Bahn*. 

Microbiology Spectrum. 2023 Sep 6;11(5):e0215223. http://doi.org/10.1128/spectrum.02152-23

등록특허: cAMP/PKA 신호전달경로 인자 저해제를 포함하는 항진균 보조용 조성물(1027216290000, 2024.10.21)

• New secondary metabolites produced by Paraphoma radicina FB55 as potential antifungal agents. 

Yeongwoon Jin*, Kyung-Tae Lee*, Taeyeon Kim, Jaekyeong Kim, Jin Woo Lee, and Sang Hee Shim*. 

Journal of Antibiotics. 2023 Aug;76(8):474-480. http://doi.org/s41429-023-00626-x

• Bub1 kinase acts as a signalling hub for the entire Cryptococcus neoformans spindle assembly checkpoint pathway. 

Ioanna Leontiou, Thomas Davies, Ivan Clark, Koly Aktar, Ardra Pamburayath Suresh, Maria Alba Abad, Christos Spanos, Kyung-Tae Lee, Yong-Sun Bahn, A. Arockia Jeyaprakash, and Kevin G. Hardwick*. 

bioRxiv 2022 September. https://doi.org/10.1101/2022.09.21.508923

• The novel antifungal agent AB-22 displays in vitro activity against hyphal growth and biofilm formation in Candida albicans and potency for treating systemic candidiasis.

Lee KT*, Lee DG, Choi JW, Park JH, Park KD, Lee JS*, YS Bahn*. 

Journal of Microbiology 2022 April, 60(4):438-443. http://doi.org/10.1007/s12275-022-2016-0 

• Optimization and evaluation of novel antifungal agents for the treatment of fungal infection. 

Choi JW*, Lee KT*, Kim S, Lee, YR, Kim H, Seo KJ, Lee MH, Yeon SK, Jang BK, Park SJ, Kim HJ, Park JH, Kim D, Lee DG, Cheong E, Lee JS*, Bahn YS*, Park KD*. 

Journal of Medicinal Chemistry 2021 October, 64(21):15912–15935. http://doi.org/10.1021/acs.jmedchem.1c01299 (2020 IF=7.446, JIF 4.03% in Medicinal Chemistry, Selected as a cover article)

등록특허: 신규한 아미노알칸산에 바이페닐기를 도입한 유도체 화합물 및 이를 포함하는 항진균성 약학적 조성물(1022868970000, 2021.08.02)

• Adenylyl cyclase and protein kinase A play redundant and distinct roles in growth, differentiation, antifungal drug resistance, and pathogenicity of Candida auris. 

Kim JS*, Lee KT, Lee MH, Cheong E, Bahn YS*. 

mBio 2021 October, 12(5):e02729-21. http://doi.org/10.1128/mBio.02729-21 

• Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood-brain barrier. 

Kim J*, Lee KT*, Lee JS, Shin J, Cui B, Yang K, Choi N, Lee SH, Cheon J, Bahn YS*, Cho SW*. 

Nature Biomedical Engineering 2021 August, 5(8):830-846. http://doi.org/10.1038/s41551-021-00743-8 (2020 IF=25.671, JIF 0.56%, Selected as a cover article)

• A signature-tagged mutagenesis (STM)-based murine-infectivity assay for Cryptococcus neoformans. 

Jung KW*, Lee KT, Bahn YS*. 

Journal of Microbiology 2020 October, 58(10):823-831. http://doi.org/10.1007/s12275-020-0341-8 

• Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans.

Jin JH*, Lee KT*, Hong J, Lee D, Jang EH, Kim JY, Lee Y, Lee SH, So YS, Jung KW, Lee DG, Jeong E, Lee M, Jang, YB, Choi Y, Lee MH, Kim JS, Yu SR, Choi, JT, La JW, Choi H, Kim SW, Seo KJ, Lee Y, Thak EJ, Choi J, Averette AF, Lee YH, Heitman J, Kang HA, Cheong E, Bahn YS*. 

Nature Communications 2020 August, 11:4212. http://doi.org/10.1038/s41467-020-18028-0 (2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences)

    등록특허 7건 

크립토코커스 네오포르만스의 체온에 대한 내열성을 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법(1025187420000, 2021.11.17)

크립토코커스 네오포르만스의 혈액뇌장벽 통과를 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법(1025187640000, 2021.11.17)

크립토코커스 네오포르만스의 멜라닌 생산을 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법(1025187500000, 2023.04.03)

크립토코커스 네오포르만스의 다당류 캡슐 생산을 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법(1025187560000, 2023.04.03)

크립토코커스 네오포르만스의 세포막 안정성을 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법(1025187850000, 2023.04.03)

크립토코커스 네오포르만스의 DNA 손상 반응을 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법(1025187690000, 2023.04.03)

크립토코커스 네오포르만스의 O-만노실화를 조절하는 포스파타아제 및 이를 이용한 항진균제 스크리닝 방법(1025187860000, 2023.04.03)

• Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans. 

Lee KT*, Hong J*, Lee DG*, Lee M, Cha S, Lim YG, Jung KW, Hwangbo A, Lee Y, Yu SJ, Chen YL, Lee JS, Cheong E*, Bahn YS*. 

Nature Communications 2020 March, 11:1521. http://doi.org/10.1038/s41467-020-15329-2 (2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences)

• Regulatory mechanism of the atypical AP-1-like transcription factor Yap1 in Cryptococcus neoformans. 

So YS*, Maeng S*, Yang DH, Kim H, Lee KT, Yu SR, Tenor J, Giri VK, Toffaletti DL, Arras S, Fraser JA, Perfect JR, Bahn YS*. 

mSphere 2019 November, 4(6):e00785-19. http://doi.org/10.1128/mSphere.00785-19 

• Unraveling melanin biosynthesis and signaling networks in Cryptococcus neoformans. 

Lee D*, Jang EH, Lee M, Kim SW, Lee Y, Lee KT, Bahn YS*. 

mBio 2019 October, 10(5):e02267-19. http://doi.org/10.1128/mBio.02267-19 (Editor's Pick)

• Biosynthesis of nonimmunosuppressive FK506 analogues with antifungal activity. 

Beom JY*, Jung JA*, Lee KT*, Hwangbo A*, Song MC, Lee Y, Lee SJ, Oh JH, HA SJ, Nam SJ, Cheong E*, Bahn YS*, Yoon YJ*. 

Journal of Natural Products 2019 August, 82(8):2078-2086. http://doi.org/10.1021/acs.jnatprod.9b00144 (2020 IF=4.050, JIF 6.8% in Plant Sciences, ACS Editors’ Choice)

등록특허 2건

신규 화합물 및 이를 포함하는 진균감염 치료용 약학적 조성물(1021091680000, 2020.05.04)

신규 화합물 및 이를 포함하는 신경계 질환 치료용 약학적 조성물(1021347820000, 2020.07.10)

• In vitro and in vivo assessment of FK506 analogs as novel antifungal drug candidates. 

Lee Y*, Lee KT*, Lee SJ*, Beom JY*, Hwangbo A, Jung JA, Song MC, Yoo YJ, Kang SH, Averette AF, Heitman J, Yoon YJ*, Cheong E*, Bahn YS*. 

Antimicrobial Agents and Chemotherapy 2018 November, 62(11):e01627-18. http://doi.org/10.1128/AAC.01627-18 

• Genetic Manipulation of Cryptococcus neoformans. 

Jung KW*, Lee KT, So YS, Bahn YS*. 

Current Protocols in Microbiology 2018 August, 50(1):e59. http://doi.org/10.1002/cpmc.59 

• Evolutionarily conserved and divergent roles of unfolded protein response (UPR) in the pathogenic Cryptococcus species complex. 

Jung KW*, Lee KT, Averette AF, Hoy MJ, Everitt J, Heitman J, Bahn YS*. 

Scientific Reports 2018 May, 8(1):8132. http://doi.org/10.1038/s41598-018-26405-5 

• The novel microtubule-associated CAP-glycine protein Cgp1 governs growth, differentiation, and virulence of Cryptococcus neoformans. 

Wang LL*, Lee KT*, Jung KW, Lee DG, Bahn YS*. 

Virulence 2018 February, 9(1):566-584. http://doi.org/10.1080/21505594.2017.1423189

• Systematic analysis of the pathogenicity-related signal pathways in human meningitis fungal pathogen. 

Lee KT.

Graduate School, Yonsei University Department of Biotechnology (2018) RISS: http://www.riss.kr/link?id=T14739545 

• Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans. 

Lee KT*, So YS*, Yang DH*, Jung KW, Choi J, Lee DG, Kwon H, Jang J, Wang LL, Cha S, Meyers GL, Jeong E, Jin JH, Lee Y, Hong J, Bang S, Ji JH, Park G, Byun HJ, Park SW, Park YM, Adedoyin G, Kim T, Averette AF, Choi JS, Heitman J, Cheong E, Lee YH, Bahn YS*. 

Nature Communications 2016 September, 7:12766. http://doi.org/10.1038/ncomms12766 (2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences)

• Intron retention-dependent gene regulation in Cryptococcus neoformans. 

Gonzalez-Hilarion S, Paulet D, Lee KT, Hon CC, Lechat P, Mogensen E, Moyrand F, Proux C, Barboux R, Bussotti G, Hwang J, Coppée JY, Bahn YS, Janbon G*. 

Scientific Reports 2016 August, 6:32252. http://doi.org/10.1038/srep32252 

• Systematic functional profiling of transcription factor networks in Cryptococcus neoformans. 

Jung KW*, Yang DH*, Maeng S, Lee KT, So YS, Hong J, Choi J, Byun HJ, Kim H, Bang S, Song MH, Lee JW, Kim MS, Kim SY, Ji JH, Park G, Kwon H, Cha S, Meyers GL, Wang LL, Jang J, Janbon G, Adedoyin G, Kim T, Averette AK, Heitman J, Cheong E, Lee YH, Lee YW, Bahn YS*. 

Nature Communications 2015 April, 6:6757. http://doi.org/10.1038/ncomms7757 (2020 IF=14.919, JIF 4.86% in Mutidisciplinary Sciences)

• A ferroxidase, Cfo1, regulates diverse environmental stress responses of Cryptococcus neoformans through the HOG pathway. 

Lee KT*, Lee JW, Lee D, Jung WH, Bahn YS*. 

Mycobiology 2014 June, 42(2):152-157. http://doi.org/10.5941/MYCO.2014.42.2.152

• Distinct and redundant roles of protein tyrosine phosphatases Ptp1 and Ptp2 in governing the differentiation and pathogenicity of Cryptococcus neoformans.

Lee KT*, Byun HJ*, Jung KW*, Hong J, Cheong E, Bahn YS*. 

Eukaryotic Cell 2014 May, 13(6):796-812. http://doi.org/10.1128/EC.00069-14 

• A nudix hydrolase protein, Ysa1, regulates oxidative stress response and antifungal drug susceptibility in Cryptococcus neoformans. 

Lee KT*, Kwon H, Lee D, Bahn YS*. 

Mycobiology 2014 March, 42(1):52-58. http://doi.org/10.5941/MYCO.2014.42.1.52