Publication

HOST-PATHOGEN INTERACTION

Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood-brain barrier. 

Kim J*, Lee KT*, Lee JS, Shin J, Cui B, Yang K, Choi N, Lee SH, Cheon J, Bahn YS*, Cho SW*.

Nature Biomedical Engineering 2021 August, 5(8):830-846

2020 IF=25.671, JCR 0.56% in Engineering, Biomedical

Selected as a cover article 

The hybrid RAVE complex plays V-ATPase-dependent and -independent pathobiological roles in Cryptococcus neoformans.

Choi JT*, Choi Y, Lee Y, Lee SH, Kang S, Lee KT*, Bahn YS*.

PLoS Pathogens 2023 October

2022 IF=6.7, JCR 9.5% in Parasitology

FUNGAL SIGNALING NETWORKS

Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans. 

Lee KT*, Hong J*, Lee DG*, Lee M, Cha S, Lim YG, Jung KW, Hwangbo A, Lee Y, Yu SJ, Chen YL, Lee JS, Cheong E*, Bahn YS*.

Nature Communications 2020 March, 11:1521

2020 IF=14.919, JCR 4.86% in Mutidisciplinary Sciences

Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans. 

Jin JH*, Lee KT*, Hong J, Lee D, Jang EH, Kim JY, Lee Y, Lee SH, So YS, Jung KW, Lee DG, Jeong E, Lee M, Jang, YB, Choi Y, Lee MH, Kim JS, Yu SR, Choi, JT, La JW, Choi H, Kim SW, Seo KJ, Lee Y, Thak EJ, Choi J, Averette AF, Lee YH, Heitman J, Kang HA, Cheong E, Bahn YS*.

Nature Communications 2020 August, 11:4212

2020 IF=14.919, JCR 4.86% in Mutidisciplinary Sciences

Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans. 

Lee KT*, So YS*, Yang DH*, Jung KW, Choi J, Lee DG, Kwon H, Jang J, Wang LL, Cha S, Meyers GL, Jeong E, Jin JH, Lee Y, Hong J, Bang S, Ji JH, Park G, Byun HJ, Park SW, Park YM, Adedoyin G, Kim T, Averette AF, Choi JS, Heitman J, Cheong E, Lee YH, Bahn YS*. 

Nature Communications 2016 September, 7:12766

2020 IF=14.919, JCR 4.86% in Mutidisciplinary Sciences

Systematic functional profiling of transcription factor networks in Cryptococcus neoformans. 

Jung KW*, Yang DH*, Maeng S, Lee KT, So YS, Hong J, Choi J, Byun HJ, Kim H, Bang S, Song MH, Lee JW, Kim MS, Kim SY, Ji JH, Park G, Kwon H, Cha S, Meyers GL, Wang LL, Jang J, Janbon G, Adedoyin G, Kim T, Averette AK, Heitman J, Cheong E, Lee YH, Lee YW, Bahn YS*. 

Nature Communications 2015 April, 6:6757

2020 IF=14.919, JCR 4.86% in Mutidisciplinary Sciences

ANTIFUNGAL DRUG DEVELOPMENT

Optimization and evaluation of novel antifungal agents for the treatment of fungal infection. 

Choi JW*, Lee KT*, Kim S, Lee, YR, Kim H, Seo KJ, Lee MH, Yeon SK, Jang BK, Park SJ, Kim HJ, Park JH, Kim D, Lee DG, Cheong E, Lee JS*, Bahn YS*, Park KD*.

Journal of Medicinal Chemistry 2021 October, 64(21):15912–15935

2020 IF=7.446, JCR 4.03% in Medicinal Chemistry

Selected as a cover article

In vitro and in vivo assessment of FK506 analogs as novel antifungal drug candidates. 

Lee Y*, Lee KT*, Lee SJ*, Beom JY*, Hwangbo A, Jung JA, Song MC, Yoo YJ, Kang SH, Averette AF, Heitman J, Yoon YJ*, Cheong E*, Bahn YS*. 

Antimicrobial Agents and Chemotherapy 2018 November, 62(11):e01627-18

2020 IF=5.191, JCR 20.47% in Pharmacology&Pharmacy

Biosynthesis of nonimmunosuppressive FK506 analogues with antifungal activity

Beom JY*, Jung JA*, Lee KT*, Hwangbo A*, Song MC, Lee Y, Lee SJ, Oh JH, HA SJ, Nam SJ, Cheong E*, Bahn YS*, Yoon YJ*. Journal of Natural Products 2019 August, 82(8):2078-2086

2020 IF=4.050

ACS Editors’ Choice

The novel antifungal agent AB-22 displays in vitro activity against hyphal growth and biofilm formation in Candida albicans and potency for treating systemic candidiasis.

Lee KT*, Lee DG, Choi JW, Park JH, Park KD, Lee JS*, Bahn YS*. 

Journal of Microbiology 2022 April, 60(4):438-443

2020 IF=3.442

New secondary metabolites produced by Paraphoma radicina FB55 as potential antifungal agents.

Jin Y*, Lee KT*, Kim T, Kim J, Lee J, Shim S*

The Journal of Antibiotics 2023, 76:474–480

2022 IF=3.424